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Immu-53. Characterization Of The Genomic And Immunological Diversity Of Malignant Brain Tumors Through Multi-sector Analysis by Max Schaettler; Megan Richters; Malachi Griffith; Gavin Dunn is a Medicine article available to read on EtoBox.

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## Abstract While the degree of spatial genomic heterogeneity within primary glioblastoma (GBM) has been previously investigated, the extent of this heterogeneity in other malignant brain tumors and its connection to the local immune microenvironment remains unknown. To address this, we performed whole-exome, RNA, and TCR sequencing on multiple spatially distinct sectors from a cohort of malignant brain tumors comprised of both brain metastases and primary and recurrent GBMs. Our results suggest a striking difference in which a majority of mutations and predicted neoantigens are shared between spatially distinct regions of metastatic brain tumors in contrast to the spatial heterogeneity observed within both primary and recurrent GBMs. Additionally, despite substantial differences in immunotherapy responsiveness between brain metastases and GBM, we can detect significantly expanded T-cell clonotypes within both tumor types with some clonal frequencies exceeding 10% of intratumoral T-cells. Similar to the observed distribution of variants and neoantigens, the expanded clonotypes are more shared among spatially distinct sectors in metastatic brain tumors than in primary or recurrent G

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Author

Max Schaettler; Megan Richters; Malachi Griffith; Gavin Dunn

Publisher

Oxford University Press (OUP)

Published

2020

Language

EN

Field

Medicine (Health Sciences)