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What is LSD1 Complex Regulates EBV Reactivation about?

The study identifies the lysine-specific histone demethylase complex (LSD1, ZNF217, and CoREST) as crucial for maintaining Epstein–Barr virus (EBV) latency, with their inhibition leading to viral reactivation and increased sensitivity to ganciclovir. A CRISPR–Cas9 screen revealed that these host factors regulate H3K4 methylation, which is a key mechanism in controlling EBV

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甲甲

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EN