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Can I read Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans on EtoBox?
Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans by Erika da Cruz Guedes; Adolfo Garcia Erustes; Anderson H. F. F. Leão; César Alves Carneiro; Vanessa C. Abílio; Antonio W. Zuardi; Jaime Eduardo C. Hallak; José Alexandre Crippa; Claudia Bincoletto; Soraya S. Smaili; Patrícia Reckziegel; Gustavo J. S. Pereira is a Neuroscience article available to read on EtoBox.
What is Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans about?
Progressive neurodegenerative disorders such as Parkinson Disease (PD) lack curative or long-term treatments. At the same time, the increase of the worldwide elderly population and, consequently, the extension in the prevalence of age-related diseases have promoted research interest in neurodegenerative disorders. Caenorhabditis elegans is a free-living nematode widely used as an animal model in studies of human diseases. Here we evaluated cannabidiol (CBD) as a possible neuroprotective compound in PD using the C. elegans models exposed to reserpine. Our results demonstrated that CBD reversed the reserpine-induced locomotor alterations and this response was independent of the NPR-19 receptors, an orthologous receptor for central cannabinoid receptor type 1. Morphological alterations of cephalic sensilla (CEP) dopaminergic neurons indicated that CBD also protects neurons from reserpine-induced degeneration. That is, CBD attenuates the reserpine-induced increase of worms with shrunken soma and dendrites loss, increasing the number of worms with intact CEP neurons. Finally, we found that CBD also reduced ROS formation and α-syn protein accumulation in mutant worms. Our findings collec
Who reads Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Erika da Cruz Guedes; Adolfo Garcia Erustes; Anderson H. F. F. Leão; César Alves Carneiro; Vanessa C. Abílio; Antonio W. Zuardi; Jaime Eduardo C. Hallak; José Alexandre Crippa; Claudia Bincoletto; Soraya S. Smaili; Patrícia Reckziegel; Gustavo J. S. Pereira
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)