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Can I read Synthesis and Evaluation of a Difluoromethylene Analogue of Sphingomyelin as an Inhibitor of Sphingomyelinase on EtoBox?
Synthesis and Evaluation of a Difluoromethylene Analogue of Sphingomyelin as an Inhibitor of Sphingomyelinase by Tsutomu Yokomatsu; Hiroaki Takechi; Takeshi Akiyama; Shiroishi Shibuya; Takaaki Kominato; Shinji Soeda; Hiroshi Shimeno is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and Evaluation of a Difluoromethylene Analogue of Sphingomyelin as an Inhibitor of Sphingomyelinase about?
A sphingomyelin analogue 2, in which the long alkenyl chain and the phosphodiester moiety of sphingomyelin were replaced by a phenyl and an isosteric difluoromethylenephosphonic acid, was prepared to evaluate its inhibitory potency to sphingomyelinase. The analogue non-competitively inhibited the neutral sphingomyelinase in bovine brain microsomes with an IC 50 of 400 mM. The compound had the ability to suppress tumor necrosis factor a-induced apoptosis of PC-12 neurons at a low concentration of 0.1 mM.
Who reads Synthesis and Evaluation of a Difluoromethylene Analogue of Sphingomyelin as an Inhibitor of Sphingomyelinase?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tsutomu Yokomatsu; Hiroaki Takechi; Takeshi Akiyama; Shiroishi Shibuya; Takaaki Kominato; Shinji Soeda; Hiroshi Shimeno
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)