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Networks of gut bacteria relate to cardiovascular disease in a multi-ethnic population: the HELIUS study by Moritz V Warmbrunn; Ulrika Boulund; Judith Aron-Wisnewsky; Marcus C de Goffau; Rosamel E Abeka; Mark Davids; Lucas R F Bresser; Evgeni Levin; Karine Clement; Henrike Galenkamp; Bart Ferwerda; Bert-Jan J H van den Born; Alexander Kurilshikov; Jingyuan Fu; Aeilko H Zwinderman; Maarten R Soeters; Daniel H van Raalte; Hilde Herrema; Albert K Groen; Max Nieuwdorp is a Medicine article available to read on EtoBox.

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## Abstract ## Aims Gut microbiota have been linked to blood lipid levels and cardiovascular diseases (CVDs). The composition and abundance of gut microbiota trophic networks differ between ethnicities. We aim to evaluate the relationship between gut microbiotal trophic networks and CVD phenotypes. ## Methods and results We included cross-sectional data from 3860 individuals without CVD history from 6 ethnicities living in the Amsterdam region participating in the prospective Healthy Life in Urban Setting (HELIUS) study. Genetic variants were genotyped, faecal gut microbiota were profiled, and blood and anthropometric parameters were measured. A machine learning approach was used to assess the relationship between CVD risk (Framingham score) and gut microbiota stratified by ethnicity. Potential causal relationships between gut microbiota composition and CVD were inferred by performing two-sample Mendelian randomization with hard CVD events from the Pan-UK Biobank and microbiome genome-wide association studies summary data from a subset of the HELIUS cohort (__n__ = 4117). Microbial taxa identified to be associated with CVD by machine learning and Mendelian randomization were often

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Author

Moritz V Warmbrunn; Ulrika Boulund; Judith Aron-Wisnewsky; Marcus C de Goffau; Rosamel E Abeka; Mark Davids; Lucas R F Bresser; Evgeni Levin; Karine Clement; Henrike Galenkamp; Bart Ferwerda; Bert-Jan J H van den Born; Alexander Kurilshikov; Jingyuan Fu; Aeilko H Zwinderman; Maarten R Soeters; Daniel H van Raalte; Hilde Herrema; Albert K Groen; Max Nieuwdorp

Publisher

Oxford University Press

Published

2024

Language

EN

Field

Medicine (Health Sciences)