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Preparation of spacer-containing di-, tri-, and tetrasaccharide fragments of the circulating anodic antigen of Schistosoma mansoni for diagnostic purposes by Koen M Halkes; Henricus J Vermeer; Ted M Slaghek; Peter A.V van Hooft; Arnoud Loof; Johannis P Kamerling; Johannes F.G Vliegenthart is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The chemical synthesis of -d-GlcpA-( 133 CH 2 CH=CH 2 is described. These oligosaccharides represent fragments of the circulating anodic antigen, secreted by the parasite Schistosoma mansoni in the circulatory system of the host. The applied synthesis strategy includes the preparation of a non-oxidised backbone oligosaccharide, with a levulinoyl group at O-6 of the -d-glucose residue. After the selective removal of the levulinoyl group, the obtained hydroxyl functions were converted into carboxyl groups, using pyridinium dichromate and acetic anhydride in dichloromethane, to aord the desired glucuronic-acid-containing oligosaccharides. Subsequently, the allyl glycosides have been elongated with cysteamine to give the corresponding aminespacer-containing oligosaccharides.

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Author

Koen M Halkes; Henricus J Vermeer; Ted M Slaghek; Peter A.V van Hooft; Arnoud Loof; Johannis P Kamerling; Johannes F.G Vliegenthart

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)