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Mechanisms of Elimination, Remodeling, and Competition at Frog Neuromuscular Junctions by Albert A. Herrera; Michael J. Werle is a Neuroscience article available to read on EtoBox.

What is Mechanisms of Elimination, Remodeling, and Competition at Frog Neuromuscular Junctions about?

## Abstract Mechanisms governing synapse elimination, synaptic remodeling, and polyneuronal innervation were examined in anatomical and electrophysiological studies of frog neuromuscular junctions. There was a substantial level of polyneuronal innervation in adult junctions and this varied seasonally. Nerve terminal retraction and synapse elimination occurred during normal growth and following reinnervation. Synapse elimination was not inevitable, however. Repeated __in vivo__ observations of some identified junctions showed that polyneuronal innervation could persist for over a year, while at other junctions it arose __de novo__ by terminal sprouting. We concluded that polyneuronal innervation in adult muscles was governed by an equilibrium between processes of retraction and elimination on one hand, and sprouting and synaptogenesis on the other. Other observations revealed that structural remodeling was a common feature of adult junctions. Most often, remodeling involved the simultaneous growth and retraction of different parts of the same junction. The net result was usually junctional growth that, in small frogs, appeared to provide a good match between synaptic size and the el

Who reads Mechanisms of Elimination, Remodeling, and Competition at Frog Neuromuscular Junctions?

It is typically read by researchers, students, and practitioners in Neuroscience.

Author
Albert A. Herrera; Michael J. Werle
Publisher
John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3034)
Published
1990
Language
EN
Field
Neuroscience (Life Sciences)

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