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Early and Late Effects of Alcohol Ingestion on Blood Pressure and Endothelial Function by Paulo Fernando Dotto Bau; Claiton H.D. Bau; Alexandre A. Naujorks; Guido A. Rosito is a scholarly article available to read on EtoBox.

What is Early and Late Effects of Alcohol Ingestion on Blood Pressure and Endothelial Function about?

Previous investigations have shown a biphasic effect of alcohol on blood pressure (BP). However, there are no studies on possible simultaneous influences in endothelial function. This study aims to evaluate the early and late effects of alcohol ingestion on vascular and endothelial function parameters in healthy young men. The diameter of brachial artery (DBA), endothelium-dependent flow-mediated dilatation, endothelium-independent nitroglycerin-mediated dilatation, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate were measured 30 min before intake, 4 h after intervention (when there is a reported hypotensive effect of alcohol), and after 13 h (subsequent increase in BP). The study group consisted of 100 males aged 18-25 years who were evaluated by brachial artery ultrasound. Subjects were randomized to drink either an alcoholic (60 g of ethanol) or a similar nonalcoholic beverage. Alcohol induced a biphasic effect on SBP and DBP, with a 4-h decrease followed by an increase after 13 h. After 4 h, the alcohol-drinking group presented a DBA increase that was significant at baseline and after hyperemia but not after nitroglycerin administration. There were

Author

Paulo Fernando Dotto Bau; Claiton H.D. Bau; Alexandre A. Naujorks; Guido A. Rosito

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)

Published

2005

Language

EN