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Toxicological effects of toxic metals (cadmium and mercury) on blood and the thyroid gland and pharmacological intervention by vitamin C in rabbits by Rida Khan; Shaukat Ali; Shumaila Mumtaz; Saiqa Andleeb; Mazhar Ulhaq; Hafiz Muhammad Tahir; Muhammad Khalil Ahmad Khan; Muhammad Adeeb Khan; Hafiz Abdullah Shakir is a Environmental Science article available to read on EtoBox.

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Cadmium and mercury are non-biodegradable toxic metals that may cause many detrimental effects to the thyroid gland and blood. Vitamin C has been found to be a significant chain-breaking antioxidant and enzyme co-factor against metal toxicity and thus make them less available for animals. The current study was performed to find the effect of individual metals (cadmium and mercury), their co-administration, and the ameliorative effects of vitamin C on some of the parameters that indicate oxidative stress and thyroid dysfunction. Cadmium chloride (1.5 mg/kg), mercuric chloride (1.2 mg/kg), and vitamin C (150 mg/kg of body weight) were orally administered to eight treatment groups of the rabbits (1. control; 2. Vit C; 3. CdCl; 4. HgCl; 5. Vit C + CdCl; 6. Vit C + HgCl; 7. CdCl + HgCl, and 8. Vit C + CdCl + HgCl). After the biometric measurements of all experimental rabbits, biochemical parameters viz. triidothyronine (T), thyroxine (T), thyroid-stimulating hormone (TSH), and triglycerides were measured using commercially available kits. The results exhibited significant decline (p < 0.05) in mean hemoglobin, corpuscular hemoglobin, packed cell volume, T (0.4 ± 0.0 ng/ml), and T (26.3

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Author

Rida Khan; Shaukat Ali; Shumaila Mumtaz; Saiqa Andleeb; Mazhar Ulhaq; Hafiz Muhammad Tahir; Muhammad Khalil Ahmad Khan; Muhammad Adeeb Khan; Hafiz Abdullah Shakir

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Publons; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0944-1344)

Published

2019

Language

EN

Field

Environmental Science (Physical Sciences)