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European Concerted Action on Anticoagulation (ECAA): multicentre international sensitivity index calibration of two types of point‐of‐care prothrombin time monitor systems by L. Poller; M. Keown; N. Chauhan; A. M. H. P. Van Den Besselaar; A. Tripodi; J. Jespersen; C. Shiach; M. H. Horellou; D. Dias; N. Egberg; J. A. Iriarte; I. Kontopoulou‐Griva; B. Otridge is a Medicine article available to read on EtoBox.

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**Summary.** A multicentre modified World Health Organization (WHO)‐type international sensitivity index (ISI) calibration has been performed at 10 European Concerted Action on Anticoagulation (ECAA) national laboratories using non‐citrated whole‐blood on two point‐of‐care test (POCT) prothrombin time (PT) monitor systems, CoaguChek Mini and TAS PT‐NC, using single lots of test cards/strips. The relevant species (human and rabbit) WHO international reference preparations (IRPs) were tested with the manual PT technique on citrated plasma from the same blood donations. The ISI was calculated from the slope of the orthogonal regression line relating log PT (POCT) to log PT (IRP). The mean ISI of the CoaguChek Mini system was 1·75 and 1·13 with the prothrombin time non‐citrated Thrombolytic Assessment System (TAS PT‐NC). With the CoaguChek Mini system, seven out of 10 calibrations exceeded the current 3% WHO recommended limit for the coefficient of variation (CV) of the slope with conventional PT testing, whereas with the TAS PT‐NC system, it was eight out of 10. All the POCT calibrations had a CV of the slope < 5%. It is suggested that this level of precision be adopted as the limit o

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Author

L. Poller; M. Keown; N. Chauhan; A. M. H. P. Van Den Besselaar; A. Tripodi; J. Jespersen; C. Shiach; M. H. Horellou; D. Dias; N. Egberg; J. A. Iriarte; I. Kontopoulou‐Griva; B. Otridge

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2002

Language

EN

Field

Medicine (Health Sciences)