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The Role of Histone Deacetylases in Cardiac Energy Metabolism in Heart Diseases by Qingwen Yu; Guangyuan Zhao; Jingjing Liu; Yajie Peng; Xueli Xu; Fei Zhao; Yangyang Shi; Chengyun Jin; Ji Zhang; Bo Wei is a Medicine article available to read on EtoBox.

What is The Role of Histone Deacetylases in Cardiac Energy Metabolism in Heart Diseases about?

Heart diseases are associated with substantial morbidity and mortality worldwide. The underlying mechanisms and pathological changes associated with cardiac diseases are exceptionally complex. Highly active cardiomyocytes require sufficient energy metabolism to maintain their function. Under physiological conditions, the choice of fuel is a delicate process that depends on the whole body and organs to support the normal function of heart tissues. However, disordered cardiac metabolism has been discovered to play a key role in many forms of heart diseases, including ischemic heart disease, cardiac hypertrophy, heart failure, and cardiac injury induced by diabetes or sepsis. Regulation of cardiac metabolism has recently emerged as a novel approach to treat heart diseases. However, little is known about cardiac energy metabolic regulators. Histone deacetylases (HDACs), a class of epigenetic regulatory enzymes, are involved in the pathogenesis of heart diseases, as reported in previous studies. Notably, the effects of HDACs on cardiac energy metabolism are gradually being explored. Our knowledge in this respect would facilitate the development of novel therapeutic strategies for heart

Who reads The Role of Histone Deacetylases in Cardiac Energy Metabolism in Heart Diseases?

Author

Qingwen Yu; Guangyuan Zhao; Jingjing Liu; Yajie Peng; Xueli Xu; Fei Zhao; Yangyang Shi; Chengyun Jin; Ji Zhang; Bo Wei

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)