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Statistical Descriptors for the Size and Shape of Globular Proteins by C. Abad-Zapatero; C. Thomas Lin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Statistical Descriptors for the Size and Shape of Globular Proteins about?

The atomic structures of proteins epitomize the ideas of complexity and irregularity in three-dimensional objects. For such objects, size and shape are difficult to quantify, and therefore the development of unbiased parameters for these properties could facilitate their description. Statistical analysis of the frequency distribution of interatomic distances in protein structures of different classes has revealed two numerical descriptors that correlate with physicochemical properties of these macromolecules. The median ( p ) of the distribution correlates ( r > .98, n = 45) with variables indicative of size (e.g., molecular weight and radius of gyration). The exponent of the Box-Cox transformation X, used for converting this distribution into a symmetrical one, correlated ( r = .75, n = 43) with a general dimensionless shape parameter defined as the combination of the shape-related accessible surface ( A : ) , molecular volume ( V ) , and radius of gyration (R,) in the form s = ( A : R , / V ) . It is suggested that for globular proteins X is a function of both the shape parameter s and the fractal dimension D of the protein surface. These objective descriptors of size and shape c

Who reads Statistical Descriptors for the Size and Shape of Globular Proteins?

Author

C. Abad-Zapatero; C. Thomas Lin

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0006-3525)

Published

1990

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)