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What is Aquaporin 4 about?

This document summarizes recent advances in understanding neuromyelitis optica (NMO), an inflammatory demyelinating disorder of the central nervous system. Key points include: 1) NMO was previously thought to be a variant of multiple sclerosis, but the discovery of circulating IgG antibodies against the astrocyte water channel aquaporin-4 (AQP4) revealed it to be a distinct disease. 2) AQP4-IgG is involved in the pathogenesis of NMO by binding to AQP4 on astrocytes and activating complement-dependent cyt

Author

Anonymous vnv6QF

Language

EN