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Dose–Volume Evaluation of Whole-ventricular Radiotherapy for Localised Intracranial Germinomas by M. Amin Mosleh-Shirazi; E. Raggi; F.H. Saran is a Medicine article available to read on EtoBox.

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The results of 2 general population screening studies from Europe and the US are awaited, but no reduction in mortality has been achieved so far. It is likely that only a subset of high risk men will benefit from screening. IMPACT aims to establish a prostate cancer screening programme in men with BRCA1 and BRCA2 mutations to determine the incidence and pathology of prostate cancer and the sensitivity and specificity of PSA testing in this group. Methods: Five hundred BRCA1 mutation carriers and 350 BRCA2 mutation carriers aged 40e69 years will be recruited over 5 years in 39 international centres. Eight hundred and fifty controls will be recruited from men who are predictive test negative for a known familial mutation in BRCA1 or BRCA2. Annual PSA will be taken. If the PSA is above 3.0, prostate biopsy will be offered. This will be the largest prostate cancer screening study in men with a known genetic mutation. Results: 40 men have been recruited to date, comprising 18 BRCA2 carriers, 13 BRCA1 carriers and 9 controls. Three men have PSA levels above our threshold, a BRCA1 mutation carrier, a BRCA2 mutation carrier and a control. Their PSA levels are 3.8, 6.7 and 7.2, respectively

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Author

M. Amin Mosleh-Shirazi; E. Raggi; F.H. Saran

Publisher

Elsevier Science; Springer; Elsevier ; Springer-Verlag; W. B. Saunders Co., Ltd.; Springer Verlag; Elsevier BV; Springer Science and Business Media LLC (ISSN 1433-2981)

Published

2007

Language

EN

Field

Medicine (Health Sciences)