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Choline Acetyltransferase-immunoreactive Neurons in the Developing Rat Retina by In-Beom Kim; Eun-Jin Lee; Mun-Kyu Kim; Dae-Kyoon Park; Myung-Hoon Chun is a Neuroscience article available to read on EtoBox.

What is Choline Acetyltransferase-immunoreactive Neurons in the Developing Rat Retina about?

The development of cholinergic cells in the rat retina has been examined with immunocytochemistry by using antisera against choline acetyltransferase (ChAT). ChATimmunoreactive (IR) cells were first detected at embryonic day 17 (E17) in the transitional zone between the neuroblastic layer (NBL) and ganglion cell layer (GCL). At E20, ChAT-IR cells are located exclusively in the GCL. At postnatal day 0 (P0), ChAT immunoreactivity appeared for the first time in cells at the distal margin of the NBL. Two prominent bands of labeled processes were first visible at P3, and by P15, these two bands resembled those of the adult retina. In addition, ChAT immunoreactivity appeared transiently in horizontal cells from P5 to P10. The number of ChAT-IR cells increased steadily up to P15. This resulted in a 93.8-fold increase between E17 and P15 (680 -63,800 cells). However, after P15, the number declined by 19% from 63,800 cells at P15 to 51,800 in the adult. At all ages, the spatial density of each ChAT-IR cell population in the central retina was higher than in the periphery. In both central and peripheral regions, the peak density of ChAT-IR cells in the GCL was attained at E20. However, in th

Who reads Choline Acetyltransferase-immunoreactive Neurons in the Developing Rat Retina?

Author

In-Beom Kim; Eun-Jin Lee; Mun-Kyu Kim; Dae-Kyoon Park; Myung-Hoon Chun

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

2000

Language

EN

Field

Neuroscience (Life Sciences)