About this Materials Science article

Generic Method for Designing Self-Standing and Dual Porous 3D Bioscaffolds from Cellulosic Nanomaterials for Tissue Engineering Applications by Tamilselvan Mohan; Andreja Dobaj Štiglic; Marco Beaumont; Johannes Konnerth; Fazilet Gürer; Damjan Makuc; Uroš Maver; Lidija Gradišnik; Janez Plavec; Rupert Kargl; Karin Stana Kleinschek is a Materials Science article available to read on EtoBox.

Three-dimensional scaffolds (3D) with controlled shape, dual porosity and long-term mechanical and dimensional stability in biofluids are of interest as biotemplates in tissue engineering. Herein, self-standing and lightweight cellulose-based biogenic scaffolds with a spatially structured morphology, macropores and interconnected micropores were fabricated using a combination of direct ink writing 3D printing and freeze-drying techniques. This was achieved by developing a water-based and low-cost bicomponent ink based on commercially available nanofibrillated cellulose (NFC) and carboxymethyl cellulose (CMC). Physical cross-linking through dehydrothermal treatment significantly increased the surface hardness, indentation modulus, compression strength, as well as the dimensional stability of the scaffolds in biofluids, in comparison to untreated materials. However, no differences in the spectra of solid state nuclear magnetic resonance or infrared were observed for dehydrothermal treated samples, suggesting that the increase of mechanical properties and dimensional stability is based on the physical cross-linking of functional groups both at the interface between NFC and CMC. The su

Author

Tamilselvan Mohan; Andreja Dobaj Štiglic; Marco Beaumont; Johannes Konnerth; Fazilet Gürer; Damjan Makuc; Uroš Maver; Lidija Gradišnik; Janez Plavec; Rupert Kargl; Karin Stana Kleinschek

Publisher

American Chemical Society (ACS)

Published

2020

Language

EN

Field

Materials Science (Physical Sciences)