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Y chromosome sequence variation of common forensic STR markers and their flanking regions among Polish population by Maria Wróbel; Agnieszka Parys-Proszek; Magdalena Marcińska; Tomasz Kupiec is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Y chromosome sequence variation of common forensic STR markers and their flanking regions among Polish population about?

A C T Y-chromosome STR markers' analysis is widely used as a procedure with examination of sexual assault cases, kinship cases and identification of human remains. At present massively parallel sequencing (MPS) technology proves to be reliable method in analysis of DNA mixtures or low quality of DNA samples. In cases of frequent Y-STR haplotypes, sequence analysis of an allele and flanking region also gives a chance to distinguish microhaplotypes of the samples. In this study authors investigated DNA sequence variability within the Y-STR markers in polish population (reference samples and bone samples). MPS was carried on with Illumina's ForenSeq kit on the MiSeq FGx instrument. Revealed microhaplotypes and their frequency differ between markers. Some of the analyzed sequences showed no variability in the analyzed set of samples. Confronting the population data with the case samples showed that this type of information can significantly improve kinship calculation and mixture analysis.

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Author

Maria Wróbel; Agnieszka Parys-Proszek; Magdalena Marcińska; Tomasz Kupiec

Publisher

Elsevier BV

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)