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Body Mass Index, Residual Psychotic Symptoms, and Inflammation Associated with Brain Volume Reduction in Older Patients with Schizophrenia by Tsai, ShangâYing; Sajatovic, Martha; Hsu, JungâLung; Chung, KuoâHsuan; Chen, PaoâHuan; Huang, YuâJui is a Medicine article available to read on EtoBox.

What is Body Mass Index, Residual Psychotic Symptoms, and Inflammation Associated with Brain Volume Reduction in Older Patients with Schizophrenia about?

## Method: Clinically stable outpatients with schizophrenia (dsm-iv) aged ≥50 years were recruited to undergo whole-brain magnetic resonance imaging. we measured patients' plasma levels of soluble tumor necrosis factor receptor-1, soluble interleukin (il)-2 receptor (sil-2r), il-1β, and il-1 receptor antagonist (il-1ra). clinical data were obtained from medical records and interviewing patients along with their reliable others. ## Results: There were 32 patients with mean age 58.8 years in this study. multivariate regression analysis found only higher bmi significantly associated with lower volume of total gray matter, bilateral orbitofrontal and prefrontal cortexes, and the right hippocampal and frontal cortexes. increased intensity of residual symptoms (higher positive and negative syndrome scale scores) was related to lower volumes of frontal lobe, prefrontal cortex, insula, hippocampus, left hemisphere amygdala, and total white matter. the lower volume of left anterior cingulum was associated with older age and higher sil-2r plasma level; and higher il-1ra level was associated with greater right anterior cingulate volume. older age at illness onset was significantly associated

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Author

Tsai, ShangâYing; Sajatovic, Martha; Hsu, JungâLung; Chung, KuoâHsuan; Chen, PaoâHuan; Huang, YuâJui

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0885-6230)

Published

2020

Language

EN

Field

Medicine (Health Sciences)