Can I read Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma: TP53 VARIATION AND ADVANCED OVARIAN CANCER on EtoBox?

Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma: TP53 VARIATION AND ADVANCED OVARIAN CANCER by Yun Wang; Pedro Kringen; Gunnar B. Kristensen; Ruth Holm; Mark M.O. Baekelandt; Magali Olivier; Hanne Skomedal; Pierre Hainaut; Claes G. Tropé; Vera M. Abeler; Jahn M. Nesland; Anne-Lise Børresen-Dale; Åslaug Helland is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma: TP53 VARIATION AND ADVANCED OVARIAN CANCER about?

This study was conducted to evaluate the frequency and prognostic impact of TP53 alterations stratified for the TP53 codon 72 polymorphism (c.215G4C, p.Arg72Pro) in a cohort of 109 patients with advanced ovarian carcinomas. TP53 sequence variants were observed in 80 of the 109 (73.4%) tumors and were significantly associated with grade of differentiation (P=0.001). A tendency towards higher frequency of sequence variants in tumors with higher FIGO stages was seen (P=0.05). The type of TP53 sequence variant (transition A:T4G:C vs. G:C4A:T at CpG dinucleotides, and transversion G:C4T:A) had significant correlation with patients' age (P=0.04) with more A:T4G:C in patients over 60 years old. No significant associations were found between frequency of sequence variants and age at diagnosis, histological type, size of residual tumor after primary surgery, or long-term survival. Analyses of the codon 72 polymorphism in tumor DNA gave a higher frequency of homozygosity/hemizygosity than expected from the population frequency, particularly for the Pro allele. Tumors homozygous or hemizygous for the Pro allele had significantly higher frequency of TP53 sequence variants, particularly of the

Who reads Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma: TP53 VARIATION AND ADVANCED OVARIAN CANCER?

Author

Yun Wang; Pedro Kringen; Gunnar B. Kristensen; Ruth Holm; Mark M.O. Baekelandt; Magali Olivier; Hanne Skomedal; Pierre Hainaut; Claes G. Tropé; Vera M. Abeler; Jahn M. Nesland; Anne-Lise Børresen-Dale; Åslaug Helland

Publisher

Hindawi Limited

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)