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Pharmacological Studies of Ricin in Mice and Humans by Aslak Godal; Øystein Fodstad; Kristian Ingebrigtsen; Alexander Pihl is a Medicine article available to read on EtoBox.

What is Pharmacological Studies of Ricin in Mice and Humans about?

A highly sensitive enzyme-linked immunosorbent assay (ELISA) for determination of ricin in serum is presented. Using this method it was found that IV-injected ricin disappeared from the plasma of mice and cancer patients according to first-order kinetics. DBA mice were found to be more sensitive to ricin than C3H and B6D2 mice. When mice of the different strains were given the same dose of ricin, the concentrations found in liver, spleen, and kidneys were highest in the most sensitive mice. Ricin disappeared most rapidly from serum of the mice with the highest sensitivity. The inverse correlation between the rate of disappearance of ricin from serum and the tissue concentrations reached may be due to the fact that ricin is rapidly and firmly bound to cell surface receptors. Whole-body autoradiography after IV injection of 125I-labeled ricin showed the highest amount of radioactivity in liver, spleen, and adrenal cortex. Considerable amounts of radioactivity were also present in bone marrow, showing that the lack of myelosuppressive activity of ricin previously found in mice and dogs cannot be accounted for by the failure of ricin to reach the bone marrow. Part of the ricin in the t

Who reads Pharmacological Studies of Ricin in Mice and Humans?

Author

Aslak Godal; Øystein Fodstad; Kristian Ingebrigtsen; Alexander Pihl

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0344-5704)

Published

1983

Language

EN

Field

Medicine (Health Sciences)