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The effect of HMGA1 in LPS-induced Myocardial Inflammation by Cai, Zhu-Lan; Shen, Bo; Yuan, Yuan; Liu, Chen; Xie, Qing-Wen; Hu, Tong-Tong; Yao, Qi; Wu, Qing-Qing; Tang, Qi-Zhu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The effect of HMGA1 in LPS-induced Myocardial Inflammation about?

**Aims**: The High Mobility Group A1 (HMGA1) proteins, serving as a dynamic regulator of gene transcription and chromatin remodeling, play an influential part in the pathological process of a large number of cardiovascular diseases. However, the precise role of HMGA1 in sepsis induced cardiomyopathy (SIC) remains unintelligible. This research was designed to illustrate the effect of HMGA1 involved in SIC. **Methods and Results**: Cardiomyocyte-specific HMGA1 overexpression was obtained using an adeno-associated virus system with intramyocardial injection in mice heart. The model of SIC in mice was constructed via intraperitoneal injection of lipopolysaccharide (LPS) for 6h. H9c2 rat cardiomyocytes was stimulated with LPS for 12h. HMGA1 expression was upregulated in murine inflammatory hearts as well as LPS stimulated H9c2 cardiomyocytes. HMGA1-overexpressing exhibited aggravated cardiac dysfunction, cardiac inflammation as well as cells apoptosis following LPS treatment both in vivo and __in vitro__ experiment. Interestingly, HMGA1 knockdown in H9c2 cardiomyocytes attenuated LPS-induced cardiomyocyte inflammation, but aggravated cell apoptosis. Mechanistically, we found that overex

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Author

Cai, Zhu-Lan; Shen, Bo; Yuan, Yuan; Liu, Chen; Xie, Qing-Wen; Hu, Tong-Tong; Yao, Qi; Wu, Qing-Qing; Tang, Qi-Zhu

Publisher

Ivyspring International Publisher; Bluehaven (N.S.W.): Ivyspring International, 2004- (ISSN 1449-2288)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)