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New efficient access to fused (Het)Aryltetrahydroindolizinones via N-acyl iminium intermediates by Matteo Chiurato; Rajaa Boulahjar; Sylvain Routier; Yves Troin; Gérald Guillaumet is a Chemistry article available to read on EtoBox.

What is New efficient access to fused (Het)Aryltetrahydroindolizinones via N-acyl iminium intermediates about?

In this paper, we described the preparation of fused (Het)Aryltetrahydroindolizinones via N-acyl iminium intermediates. Two different routes were also explored to achieve the synthesis. The first one consists in the intramolecular reaction of b-hydroxylactams whereas the second route one is an intermolecular condensation between a 2-formylester or a b-alkoxylactone and an appropriate primary amine. We also developed two heterocyclic strategies to obtain the adequate unavailable starting materials in pyridine, pyrazine, quinoline, and quinaxoline series and then perform all inter or intramolecular reactions. Scope and limitations are given.

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Author

Matteo Chiurato; Rajaa Boulahjar; Sylvain Routier; Yves Troin; Gérald Guillaumet

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)