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Cardiac autonomic dysinnervation and myocardial blood flow in long-term Type 1 diabetic patients by N. Hattori; J. Rihl; F. M. Bengel; S. G. Nekolla; E. Standl; M. Schwaiger; O. Schnell is a Medicine article available to read on EtoBox.
What is Cardiac autonomic dysinnervation and myocardial blood flow in long-term Type 1 diabetic patients about?
## Abstract **Aims** The aim of the study was to assess scintigraphically the relationship between myocardial blood flow response and sympathetic dysinnervation in long‐term Type 1 diabetic patients. Effects of the iron chelator deferoxamine on myocardial blood flow were studied and they were investigated according to the presence of cardiac sympathetic dysfunction. **Methods** Myocardial blood flow (MBF) was assessed with N‐13 ammonia positron emission tomography in 13 long‐term Type 1 diabetic patients and 13 control subjects at rest and in response to sympathetic stimulation (cold pressor test (CPT)). In diabetic patients, the study was repeated after preinfusion with deferoxamine. Furthermore, ^123^I metaiodobenzylguanidine (MIBG) scintigraphy was applied to assess regional cardiac sympathetic dysinnervation (uptake score 1 = normal, homogeneous uptake ... 6 = no uptake). **Results** In diabetic patients, MBF increased in response to CPT from 78 ± 18 ml/100 g/min to 84 ± 26 ml/100 g (8%, __P__ < 0.001). Control subjects demonstrated an increase from 63 ± 17 ml/100 g to 84 ± 26 ml/100 g (33%, __P__ < 0.001), respectively. Resting MBF was higher in diabetic patients than in contr
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- Author
- N. Hattori; J. Rihl; F. M. Bengel; S. G. Nekolla; E. Standl; M. Schwaiger; O. Schnell
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3071)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)