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External pH modulation during the growth of Vibrio tapetis , the etiological agent of Brown Ring Disease by Rahmani, Alexandra; Mathien, Clémentine; Bidault, Adeline; Le Goà̄c, Nelly; Paillard, Christine; Pichereau, Vianney is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Aims Brown Ring Disease (BRD) is an infection of the Manila clam Ruditapes philippinarum due to the pathogen Vibrio tapetis. During BRD, clams are facing immunodepression and shell biomineralization alteration. In this paper, we studied the role of pH on the growth of the pathogen and formulated hypothesis on the establishment of BRD by V. tapetis. ## Methods and Results In this study, we monitored the evolution of pH during the growth of V. tapetis in a range of pH and temperatures. We also measured the pH of Manila clam hemolymph and extrapallial fluids during infection by V. tapetis. We highlighted that V. tapetis modulates the external pH during its growth, to a value of 7.70. During the development of BRD, V. tapetis also influences extrapallial fluids and hemolymph pH in vitro in the first hours of exposure and in vivo after 3 days of infection. ## Conclusions Our experiments have shown a close interaction between V. tapetis CECT4600, a pathogen of Manila clam that induces BRD, and the pH of different compartments of the animals during infection. These results indicate that that the bacterium, through a direct mechanism or as a consequence of physiological changes encounte

Who reads External pH modulation during the growth of Vibrio tapetis , the etiological agent of Brown Ring Disease?

Author

Rahmani, Alexandra; Mathien, Clémentine; Bidault, Adeline; Le Goà̄c, Nelly; Paillard, Christine; Pichereau, Vianney

Publisher

Oxford University Press (OUP)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)