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Anaphylaxis and Cardiovascular Disease: Therapeutic Dilemmas by P. Lieberman; F. E. R. Simons is a Medicine article available to read on EtoBox.
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## Summary Cardiovascular disease (CVD) increases the risk of severe or fatal anaphylaxis, and some medications for CVD treatment can exacerbate anaphylaxis. The aim of this article is to review the effect of anaphylaxis on the heart, the potential impact of medications for CVD on anaphylaxis and anaphylaxis treatment, and the cardiovascular effects of epinephrine. The therapeutic dilemmas arising from these issues are also discussed and management strategies proposed. PubMed searches were performed for the years 1990–2014 inclusive, using terms such as angiotensin‐converting enzyme (ACE) inhibitors, adrenaline, allergic myocardial infarction, anaphylaxis, angiotensin‐receptor blockers (ARBs), beta‐adrenergic blockers, epinephrine, and Kounis syndrome. Literature analysis indicated that: cardiac mast cells are key constituents of atherosclerotic plaques; mast cell mediators play an important role in acute coronary syndrome (ACS); patients with CVD are at increased risk of developing severe or fatal anaphylaxis; and medications for CVD treatment, including beta‐adrenergic blockers and ACE inhibitors, potentially exacerbate anaphylaxis or make it more difficult to treat. Epinephrine
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- Author
- P. Lieberman; F. E. R. Simons
- Publisher
- Wiley
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)