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Defining the Relationship Between Pain Intensity and Disease Activity in Patients with Rheumatoid Arthritis: a Secondary Analysis of Six Studies by Fowzia Ibrahim; Margaret Ma; David L. Scott; Ian C. Scott is a Medicine article available to read on EtoBox.
What is Defining the Relationship Between Pain Intensity and Disease Activity in Patients with Rheumatoid Arthritis: a Secondary Analysis of Six Studies about?
## Abstract ## Background Pain is the main concern of patients with rheumatoid arthritis (RA) while reducing disease activity dominates specialist management. Disease activity assessments like the disease activity score for 28 joints with the erythrocyte sedimentation rate (DAS28-ESR) omit pain creating an apparent paradox between patients’ concerns and specialists’ treatment goals. We evaluated the relationship of pain intensity and disease activity in RA with three aims: defining associations between pain intensity and disease activity and its components, evaluating discordance between pain intensity and disease activity, and assessing temporal changes in pain intensity and disease activity. ## Methods We undertook secondary analyses of five trials and one observational study of RA patients followed for 12 months. The patients had early and established active disease or sustained low disease activity or remission. Pain was measured using 100-mm visual analogue scales. Individual patient data was pooled across all studies and by types of patients (early active, established active and established remission). Associations of pain intensity and disease activity were evaluated by corr
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- Author
- Fowzia Ibrahim; Margaret Ma; David L. Scott; Ian C. Scott
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)