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This document describes a study that optimized the formulation of orally disintegrating tablets (ODT) containing meloxicam nanoparticles. Meloxicam was milled into nanoparticles using high-energy milling and then formulated into ODTs using direct compression. Different proportions of Ac-Di-Sol and Kollidon CL superdisintegrants were evaluated using a simplex lattice design to determine the optimal ratio. The optimal formula was found to be 4.05 mg of Ac-Di-Sol and 10.95 mg of Kollidon CL in a 150 mg ODT, wh

Author

Lilia Andromeda

Language

EN