Opening book details…
Can I read Physiologic mechanisms of sequential products synthesis in 1,3-propanediol fed-batch fermentation by Klebsiella pneumoniae on EtoBox?
Physiologic mechanisms of sequential products synthesis in 1,3-propanediol fed-batch fermentation by Klebsiella pneumoniae by Zong-Ming Zheng; Yun-Zhen Xu; Hong-Juan Liu; Ni-Ni Guo; Zhong-Zhen Cai; De-Hua Liu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Physiologic mechanisms of sequential products synthesis in 1,3-propanediol fed-batch fermentation by Klebsiella pneumoniae about?
## Abstract The glycerol fed‐batch fermentation by __Klebsiella pneumoniae__ CGMCC 1.6366 exhibited the sequential synthesis of products, including acetate, 1,3‐propanediol (1,3‐PD), 2,3‐butanediol, ethanol, succinate, and lactate. The dominant flux distribution was shifted from acetate formation to 1,3‐PD formation in early‐ exponential growth phase and then to lactate synthesis in late‐exponential growth phase. The underlying physiological mechanism of the above observations has been investigated via the related enzymes, nucleotide, and intermediary metabolites analysis. The carbon flow shift is dictated by the intrinsic physiological state and enzymatic activity regulation. Especially, the internal redox state could serve as a rate‐controlling factor for 1,3‐PD production. The __q__~1,3‐PD~ formation was the combined outcomes of regulations of glycerol dehydratase activity and internal redox balancing. The __q__~ethanol~/__q__~acetate~ ratios demonstrated the flexible adaptation mechanism of __K. pneumoniae__ preferring ATP generation in early‐exponential growth phase. A low PEP to pyruvate ratio corresponded LDH activity increase, leading to lactate accumulation in stationary p
Who reads Physiologic mechanisms of sequential products synthesis in 1,3-propanediol fed-batch fermentation by Klebsiella pneumoniae?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zong-Ming Zheng; Yun-Zhen Xu; Hong-Juan Liu; Ni-Ni Guo; Zhong-Zhen Cai; De-Hua Liu
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 0006-3592)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)