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What is ROS in Alpha-Adrenergic Hypertrophy about?
This study tested the hypothesis that reactive oxygen species (ROS) mediate alpha-1-adrenergic receptor (α1-AR)-stimulated hypertrophic growth in adult rat ventricular myocytes. The authors found that norepinephrine (NE) stimulation of α1-AR increased intracellular ROS levels and induced manganese superoxide dismutase mRNA. NE caused hypertrophic growth characterized by increased protein synthesis and gene expression. These effects were prevented by α1-AR blockade or antioxidant treatment. However, antioxid
- Author
- flashjet
- Language
- EN