Can I read Application of dynamic mechanical analysis (DMA) to determine the mechanical properties of pellets on EtoBox?

Application of dynamic mechanical analysis (DMA) to determine the mechanical properties of pellets by Abraham B. Bashaiwoldu; F. Podczeck; J.M. Newton is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Application of dynamic mechanical analysis (DMA) to determine the mechanical properties of pellets about?

Pellets of a wide range of mechanical properties were produced by the process of extrusion and spheronisation using various formulation factors. A range of mechanical properties from a simple fracture load to detailed load/displacement curves obtained when pellets were subjected to diametral compression test and a bed of pellets was compacted, were used to provide measure of tensile strength, deformability, linear strain, elastic modulus, yield and shear strength. Such conventional techniques resulted in irreversible damage to the structure of the pellets and were unable to establish the viscoelastic properties of the pellets. The application of the dynamic mechanical analysis (DMA), however, allowed the determination of (1) an accurate Young's modulus of elasticity, which was found to be between 8.4 and 24-fold higher than that determined from the diametral compression test, (2) the presence of a reversible elastic deformation even after the yield point in terms of storage modulus and (3) a change in the values of the phase angle, which illustrates the increase in viscoelasticity of the pellets formed with ethanol, glyceryl monostearate (GMS) or glycerol, while a decrease in visco

Who reads Application of dynamic mechanical analysis (DMA) to determine the mechanical properties of pellets?

Author

Abraham B. Bashaiwoldu; F. Podczeck; J.M. Newton

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2004

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)