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Incidence of hemorrhagic cystitis after cyclophosphamide therapy with or without mesna: A cohort study and comprehensive literature review by Almalag, Haya M; Alasmari, Sarah S; Alrayes, Mounerah H; Binhameed, Munirah A; Alsudairi, Reem A; Alosaimi, Maha M; Alnasser, Ghada A; Abuzaid, Rawan A; Khalil, Najma; Abouzaid, Hanan H; Alarfaj, Abdulrahman S is a Medicine article available to read on EtoBox.

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## Background Cyclophosphamide is an alkylating agent associated with significant toxicities, most importantly hemorrhagic cystitis. Many approaches including mesna use were established to reduce this toxicity. However, data on mesna efficacy are conflicting. ## Objective To investigate the incidence of hemorrhagic cystitis in patients receiving cyclophosphamide therapy with or without mesna. ## Methods A retrospective chart review was done on all adult patients receiving cyclophosphamide therapy with or without mesna at the King Saud University Medical City. The incidence of hemorrhagic cystitis was recorded. Patients receiving mesna were compared with those not receiving mesna. Data were reported as numbers and percentages, and appropriate statistical tests of association were used. This step was followed by a comprehensive literature review using appropriate keywords in PubMed from the inception of the database until August 2019. All studies of interest were reported. ## Results A total of 718 patients’ medical records were reviewed. The majority of the patients received mesna (n = 433, 60%). The mesna group had a greater incidence of hemorrhagic cystitis (3.5% vs. 0.4%, p < 0.0

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Author

Almalag, Haya M; Alasmari, Sarah S; Alrayes, Mounerah H; Binhameed, Munirah A; Alsudairi, Reem A; Alosaimi, Maha M; Alnasser, Ghada A; Abuzaid, Rawan A; Khalil, Najma; Abouzaid, Hanan H; Alarfaj, Abdulrahman S

Publisher

SAGE Publications (ISSN 1078-1552)

Published

2020

Language

EN

Field

Medicine (Health Sciences)