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Can I read Serum Interleukin-6 and -8 as Predictors of Response to Vedolizumab in Inflammatory Bowel Diseases on EtoBox?
Serum Interleukin-6 and -8 as Predictors of Response to Vedolizumab in Inflammatory Bowel Diseases by Bertani, Lorenzo; Caviglia, Gian Paolo; Antonioli, Luca; Pellicano, Rinaldo; Fagoonee, Sharmila; Astegiano, Marco; Saracco, Giorgio Maria; Bugianesi, Elisabetta; Blandizzi, Corrado; Costa, Francesco; Ribaldone, Davide Giuseppe is a Medicine article available to read on EtoBox.
What is Serum Interleukin-6 and -8 as Predictors of Response to Vedolizumab in Inflammatory Bowel Diseases about?
Vedolizumab, a monoclonal antibody directed against integrin α4β7, is an effective treatment for inflammatory bowel diseases. However, a significant number of patients do not achieve steroid-free clinical remission in the first year of treatment. An early identification of these patients is one of the most important challenges for clinicians and offers the possibility of therapeutic optimization in order to personalize biological therapy. The aim of our study was to test the prediction ability of interleukin (IL)-6 and -8 of clinical response after 12 months of therapy with vedolizumab (T2). We performed a prospective, multicentre study in patients affected by inflammatory bowel disease by analysing cytokines level before starting vedolizumab (T0) and after 10 weeks of therapy (T1). In the overall cohort (__n__ = 54), IL-8 decrease > 2.6 pg/mL in the first 10 weeks of therapy was able to predict clinical response (area under the curve (AUC) = 0.70, sensitivity = 66%, specificity = 75%, __p__ = 0.010), negative C-reactive protein (CRP) (AUC = 0.71, sensitivity = 64%, specificity = 80%, __p__ = 0.009) and calprotectin 8.6 pg/mL and a decrease of IL-6 values > 0.4 pg/mL from T0 to T
Who reads Serum Interleukin-6 and -8 as Predictors of Response to Vedolizumab in Inflammatory Bowel Diseases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Bertani, Lorenzo; Caviglia, Gian Paolo; Antonioli, Luca; Pellicano, Rinaldo; Fagoonee, Sharmila; Astegiano, Marco; Saracco, Giorgio Maria; Bugianesi, Elisabetta; Blandizzi, Corrado; Costa, Francesco; Ribaldone, Davide Giuseppe
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI) (ISSN 2077-0383)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)