Can I read Antiproliferative Coatings for the Treatment of Coronary Heart Disease: : What Are the Targets and Which Are the tools? on EtoBox?

Antiproliferative Coatings for the Treatment of Coronary Heart Disease: : What Are the Targets and Which Are the tools? by ELLIOT J. SMITH; MARTIN T. ROTHMAN is a Medicine article available to read on EtoBox.

What is Antiproliferative Coatings for the Treatment of Coronary Heart Disease: : What Are the Targets and Which Are the tools? about?

__Since the advent of percutaneous coronary intervention (PCI) for stenosing coronary disease, restenosis has remained a clinical problem. Despite the emergence and evolution of coronary stents, the rate of restenosis following PCI is still 10–20%, and above 50% in high risk subgroups. With increased understanding of the pathophysiology of this process, a number of potential therapeutic targets have been identified, allowing the development of novel therapies against restenosis, which can now be delivered locally using stent platforms. Some of the reported clinical trial data utilizing drug‐eluting stents (DES) have produced such profound reductions in clinical and angiographic restenosis that we have been tempted to believe we are on the brink of eradicating this process completely. As the initial excitement subsides, however, there is a need to decide whether these tools will remain effective in real‐world interventional practice.__ __In this article we review the pathophysiology of the restenotic process, and the biological targets of the DES therapies currently available in clinical practice. We attempt to define clinical target populations for DES therapy, and assess the impac

Who reads Antiproliferative Coatings for the Treatment of Coronary Heart Disease: : What Are the Targets and Which Are the tools??

Author

ELLIOT J. SMITH; MARTIN T. ROTHMAN

Publisher

John Wiley and Sons; Hindawi Limited; Blackwell Publishing Inc.; Wiley (ISSN 0896-4327)

Published

2003

Language

EN

Field

Medicine (Health Sciences)