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Can I read Systematic In Silico Design, Synthesis, and Biological Studies of Some Novel 1,4-Benzoquinone Derivatives for the Prospective Management of Cognitive Decline on EtoBox?
Systematic In Silico Design, Synthesis, and Biological Studies of Some Novel 1,4-Benzoquinone Derivatives for the Prospective Management of Cognitive Decline by Silakari, Pragati (author);Silakari, Om (author);Piplani, Poonam (author) is a Neuroscience article available to read on EtoBox.
What is Systematic In Silico Design, Synthesis, and Biological Studies of Some Novel 1,4-Benzoquinone Derivatives for the Prospective Management of Cognitive Decline about?
Cholinesterases are significant biological targets for the regulation of cholinergic neurotransmission, and their inhibitors are being exploited for the management of cognitive decline in various neurological conditions. The 1,4-benzoquinone scaffold possesses antioxidant potential along with AChE inhibition activity in various neurological disorders. To design novel and potent selective 1,4-benzoquinone analogues as cholinesterase inhibitors, a ligand-based drug design strategy was followed to develop a 3D quantitative structure-selectivity relationship (QSSR) model. On the basis of the best fit model, eight novel 1,4-benzoquinone derivatives were designed and synthesized implementing appropriate synthetic procedures and were characterized by various spectral and elemental techniques. All the synthesized compounds were evaluated for their selective in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory potential at different concentrations using mice brain homogenate as the source of the enzyme. Out of these compounds, the three most selective compounds were further evaluated for behavioral variations using step down passive avoidance and escape learning
Who reads Systematic In Silico Design, Synthesis, and Biological Studies of Some Novel 1,4-Benzoquinone Derivatives for the Prospective Management of Cognitive Decline?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Silakari, Pragati (author);Silakari, Om (author);Piplani, Poonam (author)
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)
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