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Can I read Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study on EtoBox?
Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study by Shu-Feng Zhou; Junhui Su; Cui Chang; Qi Xiang; Zhi-Wei Zhou; Rong Luo; Lun Yang; Zhi-Xu He; Hongtu Yang; Jiannan Li; Yu Bei; Jinmei Xu; Minjing Zhang; Qihao Zhang; Zhijian Su; Yadong Huang; Jiyan Pang is a Medicine article available to read on EtoBox.
What is Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study about?
Natural compounds are becoming popular for the treatment of illnesses and health promotion, but the mechanisms of action and safety profiles are often unknown. Xyloketal B (XKB) is a novel marine compound isolated from the mangrove fungus __Xylaria__ sp., with potent antioxidative, neuroprotective, and cardioprotective effects. However, its molecular targets and effects on drug-metabolizing enzymes are unknown. This study aimed to investigate the potential molecular targets of XKB using bioinformatic approaches and to examine the effect of XKB on the expression and activity of rat cytochrome P450 3a (Cyp3a) subfamily members using midazolam as a model probe. DDI-CPI, a server that can predict drug–drug interactions via the chemical–protein interactome, was employed to predict the targets of XKB, and the Database for Annotation, Visualization and Integrated Discovery (DAVID) was used to analyze the pathways of the predicted targets of XKB. Homology modeling was performed using the Discovery Studio program 3.1. The activity and expression of rat hepatic Cyp3a were examined after the rats were treated with XKB at 7 and 14 mg/kg for 8 consecutive days. Rat plasma concentrations of mida
Who reads Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shu-Feng Zhou; Junhui Su; Cui Chang; Qi Xiang; Zhi-Wei Zhou; Rong Luo; Lun Yang; Zhi-Xu He; Hongtu Yang; Jiannan Li; Yu Bei; Jinmei Xu; Minjing Zhang; Qihao Zhang; Zhijian Su; Yadong Huang; Jiyan Pang
- Publisher
- Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd; [Auckland N.Z.: Dove Medical Press, 2007]-; Informa UK Limited; Dove Medical Press Ltd. (ISSN 1177-8881)
- Published
- 2014
- Language
- EN
- Field
- Medicine (Health Sciences)