Can I read Immunohistochemical Study on Expression of α‐Defensin and β‐Defensin‐2 in Human Buccal Epithelia with Candidiasis on EtoBox?

Immunohistochemical Study on Expression of α‐Defensin and β‐Defensin‐2 in Human Buccal Epithelia with Candidiasis by K Sawaki; N Mizukawa; T Yamaai; J Fukunaga; T Sugahara is a Dentistry article available to read on EtoBox.

What is Immunohistochemical Study on Expression of α‐Defensin and β‐Defensin‐2 in Human Buccal Epithelia with Candidiasis about?

OBJECTIVES AND DESIGN: It has been previously reported that __α__‐defensin (HNPs) and __β__‐defensin‐2 (HBD‐2) peptides with antifungal and cytotoxic activities can be detected in oral carcinomas and the saliva of patients with oral carcinomas. The present study investigated the presence of HNPs and HBD‐2 in oral epithelia with candidiasis. MATERIALS AND METHODS: Tissue sections (4 μm) were prepared from biopsy and surgically removed specimens diagnosed as oral candidiasis (__n__=10). The sections were examined immunohistochemically with antibodies directed against HNPs and HBD‐2. RESULTS: Tissue sections of oral candidiasis were immunostained with antidefensin antibodies. Neutrophils in the inflamed lamina propria were positively immunostained with anti‐HNPs antibody. The cytoplasm of cells in the upper spinous layer, in the lower spinous layer and in the parakeratinized layer of buccal epithelia with candidiasis was immunostained intensely with anti‐HBD‐2 antibody. In contrast, the expression of HBD‐2 in the normal spinous layer was much weaker than that in oral candidiasis. No signals of HNPs were found in normal buccal epithelium. CONCLUSION: Buccal specimens from individuals w

Who reads Immunohistochemical Study on Expression of α‐Defensin and β‐Defensin‐2 in Human Buccal Epithelia with Candidiasis?

Author

K Sawaki; N Mizukawa; T Yamaai; J Fukunaga; T Sugahara

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 1354-523X)

Published

2002

Language

EN

Field

Dentistry (Health Sciences)