Opening book details…
Can I read Normalization of non‐canonical Wnt signalings does not compromise blood‐brain barrier protection conferred by upregulating endothelial Wnt/β‐catenin signaling following ischemic stroke on EtoBox?
Normalization of non‐canonical Wnt signalings does not compromise blood‐brain barrier protection conferred by upregulating endothelial Wnt/β‐catenin signaling following ischemic stroke by Ya‐bin Ji; Tian‐xi Wang; Qiang Gao; Xiao‐wen Huang; Junlei Chang is a Neuroscience article available to read on EtoBox.
What is Normalization of non‐canonical Wnt signalings does not compromise blood‐brain barrier protection conferred by upregulating endothelial Wnt/β‐catenin signaling following ischemic stroke about?
## Abstract ## Background Endothelial canonical (Wnt/β‐catenin) and non‐canonical Wnt signalings (Wnt/PCP and Wnt/Ca^2+^) promote blood‐brain barrier (BBB) development and antagonize each other. However, the effects of ischemic stroke on endothelial canonical and non‐canonical Wnt signalings are unclear. Further, how non‐canonical Wnt signalings are influenced by upregulation of endothelial Wnt/β‐catenin signaling and subsequently affect BBB function following ischemic stroke have not been studied. ## Methods First, we determined the levels of Wnt signaling markers including TCF/LEF1 transcription activity, __Axin2__ mRNA, phospho‐JNK^Thr183/Tyr185^, and NFAT in brain endothelial cells (ECs) with the deletion of Wnt receptor __Frizzled (Fzd)__4 or __Fzd6__, the two most abundant Fzds in brain ECs. Next, we observed the effect of ischemia/reperfusion injury on Wnt signalings in brain ECs and adult mice. Last, we assessed the changes of non‐canonical Wnt signalings and BBB injury in the early stage of ischemic stroke in mice with endothelial β‐catenin activation (β‐cat mice). ## Results __Fzd4__ or __Fzd6__ deletion dampened both Wnt/β‐catenin and Wnt/PCP signalings but enhanced Wnt/
Who reads Normalization of non‐canonical Wnt signalings does not compromise blood‐brain barrier protection conferred by upregulating endothelial Wnt/β‐catenin signaling following ischemic stroke?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Ya‐bin Ji; Tian‐xi Wang; Qiang Gao; Xiao‐wen Huang; Junlei Chang
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)
More by Ya‐bin Ji; Tian‐xi Wang; Qiang Gao; Xiao‐wen Huang; Junlei Chang
Browse all works by Ya‐bin Ji; Tian‐xi Wang; Qiang Gao; Xiao‐wen Huang; Junlei Chang