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Opposite effect of ablation on early/late‐phase thromboembolic incidence in patients with atrial fibrillation: A meta‐analysis on more than 100 000 individuals by Menghui Liu; Yuanping Wang; Jie Li; Xiaodong Zhuang; Xiaohong Chen; Xiaohui Li; Xinxue Liao; Lichun Wang is a Medicine article available to read on EtoBox.
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## Abstract ## Background Atrial fibrillation (AF) is an important risk factor for thromboembolic events, for which catheter ablation represents an effective therapy for rhythm control. Intuitively, ablation may reduce the incidence of thromboembolism, but data is quite limited. ## Hypothesis Catheter ablation was associated with the fewer risk of thromboembolism compared with nonablation in patients with AF. ## Methods A systematic search was performed in PubMed, EMBASE, the Web of Science, and the Cochrane Library from inception to September 2019. Random‐effects model was used to estimate the risk ratios (RR) for the thromboembolic events between the ablation and nonablation groups. ## Results Twenty‐five studies (12 randomized controlled trials and 13 observational studies) with 104 687 participants were included. Pooled analysis suggested that ablation was associated with a 35% lower risk of total thromboembolic events compared to nonablation group (RR = 0.65; 95% CI, 0.51‐0.82; __P__ = .0003). When separated into early‐phase ( 30 days) events, ablation was associated with an increased early‐phase thromboembolism (RR = 1.96; 95% CI, 1.35‐2.83; __P__ = .0004) but a decreased lat
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- Author
- Menghui Liu; Yuanping Wang; Jie Li; Xiaodong Zhuang; Xiaohong Chen; Xiaohui Li; Xinxue Liao; Lichun Wang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; Research Square (ISSN 0160-9289)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)