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Cytotoxic sesquiterpenes from Ligularia platyglossa by Jian-Qun Liu; Mian Zhang; Chao-Feng Zhang; Huan-Yang Qi; Alan Bashall; S.W. Annie Bligh; Zheng-Tao Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cytotoxic sesquiterpenes from Ligularia platyglossa about?

Four sesquiterpene lactones including an eremophilenolide dimer, named as biligulaplenolide, 1, 8bhydroxy-1-oxo-(14a,15a eremophil-7(11),9(10)-dien-12,8a-olide, 2, 1-hydroxy-2-oxo-(14a,15a eremophil-1(10),7(11),8(9)-trien-12,8-olide, 3, 4a,8b,9a-trihydroxy-5aY-7(11)-eudesmen-12,8a-olide, 4, along with two known ones, 10a-hydroxy-1-oxo-eremophil-7(11),8(9)-dien-12,8-olide, 5, and furanoeremophil-1(10)-ene-2,9-dione, 6, were isolated from the underground organs of Ligularia platyglossa (Franch.) Hand.-Mazz. Their structures were elucidated by spectroscopic methods including single-crystal X-ray diffraction analysis (2 and 3). Their in vitro cytotoxicities against seven cancer cell lines (BGC-823, A549, HL-60, B16, SMMC-7721, BEL7402, Hela) were evaluated. Compounds 2, 3, 5 showed cytotoxic activities on HL-60 cancer cells with IC 50 in the range of 24.0 to 51.1 lM, whereas compound 3 exhibited only weak cytotoxic activity against the B16, BEL7402 and Hela cancer cells. Flow cytometric analysis indicated that compound 3 induces Hela cells to apoptotic death after 48 h treatment with 0.38 mM of this compound.

Who reads Cytotoxic sesquiterpenes from Ligularia platyglossa?

Author

Jian-Qun Liu; Mian Zhang; Chao-Feng Zhang; Huan-Yang Qi; Alan Bashall; S.W. Annie Bligh; Zheng-Tao Wang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0031-9422)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)