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Parameter Sensitivity Analysis on a Mathematical Model of Reepithelialization by Jacquelyn Dawn Parente; Knut Möller; Bala Amala Kannan; Sabine Hensler; Claudia Kuhlbach; Margareta M. Mueller is a Engineering article available to read on EtoBox.

What is Parameter Sensitivity Analysis on a Mathematical Model of Reepithelialization about?

## Abstract Reepithelialization is the single requirement to define a wound as healed when the barrier function of the skin is restored. An existing reepithelialization mathematical model (RM) simulates wound healing in vitro. This work performs a parameter sensitivity analysis on an existing RM to see how robust the model is for changing wound healing rates for application to chronic wounds (inhibition) and wound healing therapies (activation). The existing RM balances the optimal distance between cells and basal membrane segments (BMs) according to the calculation of intercellular pressure and adhesion force. The RM mimics cell behavior and their interaction by passive migration, which is the displacement of cells from its initial position. First, this work reproduces the RM. The initial case recreates the interaction of a cell with its surrounding cells, while the second case recreates the interaction of the cell with its nearest BMs. These two cases were implemented in MATLAB to estimate optimal distance, intercellular pressure, an adhesive force between cells and the BMs. The analysis computes movement vectors and new positions of each cell at different time steps. Parameter s

Who reads Parameter Sensitivity Analysis on a Mathematical Model of Reepithelialization?

Author

Jacquelyn Dawn Parente; Knut Möller; Bala Amala Kannan; Sabine Hensler; Claudia Kuhlbach; Margareta M. Mueller

Publisher

Walter de Gruyter GmbH

Published

2019

Language

EN

Field

Engineering (Physical Sciences)