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Intramatricial injections for nail psoriasis: An open-label comparative study of triamcinolone, methotrexate, and cyclosporine by Jyotisterna Mittal; BharatBhushan Mahajan is a Medicine article available to read on EtoBox.

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## Background: One of the most effective options available for treating psoriatic fingernails is intramatricial injection of triamcinolone acetonide. efficacies of intramatricial methotrexate and cyclosporine have not been comparatively evaluated to date. ## Methods: Ninety fingernails in 17 patients were assigned to three groups of thirty nails each, and treated with intramatricial injections of triamcinolone acetonide (10 mg/ml), methotrexate (25 mg/ml) and cyclosporine (50 mg/ml) respectively. each nail was given two injections with a 6-week interval, and graded at 24 weeks using the nail psoriasis severity index. ## Results: In both triamcinolone acetonide and methotrexate groups, 15 (50%) nails out of 30 showed >75% improvement. in the cyclosporine group, only ten (33%) nails showed >75% improvement. side effects were most in the nails treated with cyclosporine. ## Limitations: The limited follow-up period of 24 weeks may have been insufficient for detecting delayed remissions. the number of patients was small and there was no randomization or blinding. the lack of a placebo/ no- treatment arm can be considered a limitation. ## Conclusions: Amongst the three drugs studied, int

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Author

Jyotisterna Mittal; BharatBhushan Mahajan

Publisher

Scientific Scholar

Published

2018

Language

EN

Field

Medicine (Health Sciences)