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Separation of rat thyroid lysosome subpopulations on Sepharose 2B by Raymond Miquelis; Claude Penel; Claude Simon is a Chemistry article available to read on EtoBox.

What is Separation of rat thyroid lysosome subpopulations on Sepharose 2B about?

Separatian cd rat thyroid tysascme subpoputations an Sephamse 28 Although gel cbromatogmpby is widely used for molecular fractionation, it has rarely been used for subcell&r fractionation. This paper describes an attempt to separate a crude thyroid Iysosomal population into subpopuiations, characterized by the dtxia of age and size, using Sepharose 2B gel, Thyroid lysosomes are involved in the degradation of t@oglobulin (Tg), an iodinated glycoprotein that is the source of thyroid hormones. The intralysosomal hydrolysis of Tg is known to be heterogeneous, as recently iodinated (ney) Tg is hydroiysed faster than the previously iodinated (old) Tgl\*L; thus, one cam consider that, taking the iodine specific radioactivity (SRA = new label/old label) as an inhex, the higher the SRA the younger is the lysosome. The size distribution of organelks was studied by moHphometry\_ A relationship between the size distribution of the iysosomes and the mean -age" of their iodine content has been found and could be interpreted as sepantion of the lysosomes into physiological subpopulations.

Who reads Separation of rat thyroid lysosome subpopulations on Sepharose 2B?

Author

Raymond Miquelis; Claude Penel; Claude Simon

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

1980

Language

EN

Field

Chemistry (Physical Sciences)