Opening book details…
Can I read Effect of Coadministration of Uracil on the Toxicity of Tegafur on EtoBox?
Effect of Coadministration of Uracil on the Toxicity of Tegafur by Jyunji Yamamoto; Akihiro Haruno; Yuji Yoshimura; Norio Unemi; Yoshio Kunimune; Kazumasa Yamashita; Ken'Ichi Morita is a Chemistry article available to read on EtoBox.
What is Effect of Coadministration of Uracil on the Toxicity of Tegafur about?
The cardiotoxic and neurotoxic effects of tegafur, an anticancer agent, were compared with those of uracil plus tegafur (4:1 mol/mol) in mice, rats, rabbits, cats and dogs. Uracil plus tegafur was shown to be less toxic than the drug alone in all the species, and uracil was found to decrease the toxicity of tegafur. alpha-Fluoro-beta-alanine, a catabolic metabolite of the drug, had toxic effects similar to tegafur. The results suggest that administration of uracil with tegafur prevents the side effects of the drug on the heart and CNS by inhibiting the degradation of 5-fluorouracil.
Who reads Effect of Coadministration of Uracil on the Toxicity of Tegafur?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Jyunji Yamamoto; Akihiro Haruno; Yuji Yoshimura; Norio Unemi; Yoshio Kunimune; Kazumasa Yamashita; Ken'Ichi Morita
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)
- Published
- 1984
- Language
- EN
- Field
- Chemistry (Physical Sciences)