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Can I read Synthesis and SAR of potent EGFR/erbB2 dual inhibitors on EtoBox?
Synthesis and SAR of potent EGFR/erbB2 dual inhibitors by Yue-Mei Zhang; Stuart Cockerill; Stephen B. Guntrip; David Rusnak; Kathryn Smith; Dana Vanderwall; Edgar Wood; Karen Lackey is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and SAR of potent EGFR/erbB2 dual inhibitors about?
A series of 6-alkoxy-4-anilinoquinazoline compounds was prepared and evaluated for in vitro inhibition of the erbB2 and EGFR kinase activity. The IC 50 values of the best compounds were below 0.10 uM. Further, several of these compounds inhibit the growth of erbB2 and EGFR over-expressing tumor cell lines at concentrations below 1 uM.
Who reads Synthesis and SAR of potent EGFR/erbB2 dual inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yue-Mei Zhang; Stuart Cockerill; Stephen B. Guntrip; David Rusnak; Kathryn Smith; Dana Vanderwall; Edgar Wood; Karen Lackey
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)