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Comparison of measurements from different imaging modalities for determining tumor prominence for the ruthenium irradiation of malignant uveal melanomas (MUM) by A Dogan; P Schueller; U Schaefer; O Micke; N Willich is a Medicine article available to read on EtoBox.

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determined by clinical and radiological examinations. The average field size was 12.8 ϫ 12.8 cm. A 50:50 GRID (open to closed area) was used. A single dose of 12 -20 Gy (median 15 Gy) prescribed to D max was delivered using 6 -20 Mv photons. Five patients received GRID only as these areas were previously irradiated. Ten patients received Ͼ 40 Gy external radiation following the GRID. Results: 4 patients are alive and 15 have died. Ten patients survived Ͻ 1 year, and 6 patients had up to 2 years follow-up. Three have survived more than 2 years. The overall response (local control) was 80% (7 CR, 9 PR, 3 NR, 1 NE). There was good palliation of pain and mass effect with Ͼ 50% (10/19) reduction in subjective pain assessment within 48 hours after the GRID therapy. Patients who received more than 40 Gy external RT had better outcomes than those who received less than 40 Gy (5/10 CR vs. 2/10 CR and 3/10 PR vs. 6/10 PR). Acute toxicity was acceptable. No grade 3 / 4 long-term toxicity was noted in evaluable patients. Conclusions: SFR is an excellent modality for rapid palliation of large bulky melanomas. Better results are seen with GRID followed by Ͼ 40 Gy external RT. Acute toxicity/long

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Author

A Dogan; P Schueller; U Schaefer; O Micke; N Willich

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2002

Language

EN

Field

Medicine (Health Sciences)