Opening book details…
Can I read Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression on EtoBox?
Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression by Reuben Lotan; Yoshifumi Matsushita; David Ohannesian; Dunia Carralero; David M. Ota; Karen R. Cleary; Garth L. Nicolson; Tatsuro Irimura is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression about?
Lactose-binding lectins having Mr values of approximately 14,000 (L-14.5) and approximately 35,000 Da have been found in a variety of vertebrate tissues, including normal intestine and colon, and in several types of tumors such as colon carcinomas. To determine the clinical relevance of such lectins in human colon cancer, specimens from 46 patients with colorectal carcinoma of identified Dukes' stages were selected and analyzed for the presence and amount of lactose-binding lectins by immunoblotting using a polyclonal, rabbit anti-lectin antibody followed by binding of 125I-labeled anti-rabbit IgG. The amount of a lectin having an Mr value of approximately 31,000 Da (L-31) varied among the specimens. The levels of L-31 lectin in colorectal cancer specimens from primary tumors of patients with distant metastases (Dukes' stage D) were significantly higher than were those from patients without detectable metastases (Dukes' stages B1 and B2). In contrast, among the various specimens the variation in the level of the L-14.5 lectin was smaller, and there was no correlation between the amount of this lectin and cancer stage. Immunohistochemical staining of thin sections of colorectal tumo
Who reads Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Reuben Lotan; Yoshifumi Matsushita; David Ohannesian; Dunia Carralero; David M. Ota; Karen R. Cleary; Garth L. Nicolson; Tatsuro Irimura
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)
- Published
- 1991
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)