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Decreased Dendritic Spine Density of Neurons of the Prefrontal Cortex and Nucleus Accumbens and Enhanced Amphetamine Sensitivity in Postpubertal Rats After a Neonatal Amygdala Lesion by Oscar Solis; Rubén Antonio Vázquez-Roque; Israel Camacho-Abrego; Citlalli Gamboa; Fidel De La Cruz; Sergio Zamudio; Gonzalo Flores is a Neuroscience article available to read on EtoBox.
What is Decreased Dendritic Spine Density of Neurons of the Prefrontal Cortex and Nucleus Accumbens and Enhanced Amphetamine Sensitivity in Postpubertal Rats After a Neonatal Amygdala Lesion about?
## Abstract A neonatal basolateral‐amygdala (nBLA) lesion in rats could be a potential animal model to study the early neurodevelopmental abnormalities associated with the behavioral and morphological brain changes observed in schizophrenia. Morphological alterations in pyramidal neurons from the prefrontal cortex (PFC) have been observed in postmortem schizophrenic brains, mainly because of decreased dendritic arbor and spine density. We assessed the effects of nBLA‐lesion on the dendritic morphology of neurons from the PFC and the nucleus accumbens (NAcc) in rats. nBLA lesions were made on postnatal day 7 (PD7), and later, the dendritic morphology was studied by the Golgi‐Cox stain procedure followed by Sholl analysis at PD35 (prepubertal) and PD60 (adult) ages. We also evaluated the effects of the nBLA‐lesion on locomotor activity caused by a novel environment, apomorphine, and amphetamine. Adult animals with nBLA lesions showed a decreased spine density in pyramidal neurons from the PFC and in medium spiny cells from the NAcc. An increased locomotion in a novel environment and in amphetamine‐treated adult animals with an nBLA‐lesion was observed. Our results indicate that nBLA‐
Who reads Decreased Dendritic Spine Density of Neurons of the Prefrontal Cortex and Nucleus Accumbens and Enhanced Amphetamine Sensitivity in Postpubertal Rats After a Neonatal Amygdala Lesion?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Oscar Solis; Rubén Antonio Vázquez-Roque; Israel Camacho-Abrego; Citlalli Gamboa; Fidel De La Cruz; Sergio Zamudio; Gonzalo Flores
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 2009
- Language
- EN
- Field
- Neuroscience (Life Sciences)