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Functional analysis of a vacuolar ABC transporter in wild-type Candida albicans reveals its involvement in virulence by Stephanie Theiss; Marianne Kretschmar; Thomas Nichterlein; Herbert Hof; Nina Agabian; Jörg Hacker; Gerwald A. Köhler is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Summary ATP‐driven transport proteins belonging to the ATP‐binding cassette (ABC) superfamily perform important functions in cell metabolism and detoxification. Compounds can be actively transported across membranes, including the plasma membrane or organellar membranes. The vacuole is an important organelle in fungal cells required for compartmentalization of metabolites as well as toxic substances. Sequestration into the vacuole is often energy‐dependent. We present the first isolation and molecular analysis of a vacuolar ABC transporter gene in the opportunistic fungal pathogen __Candida albicans__. The protein encoded by the __MLT1__ gene is highly similar to Multiple Drug Resistance‐associated Protein (MRP)‐like transporters of yeast and higher organisms that form the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)/MRP subfamily of ABC transporters, a class of proteins so far not characterized in __C. albicans__. __MLT1__ expression is extensively growth phase‐regulated, and gene transcripts are inducible by metabolic poisons. Gene replacement mutants generated in wild‐type __C. albicans__ with the dominant selection marker __MPA^R^__ showed a profound reduction
Who reads Functional analysis of a vacuolar ABC transporter in wild-type Candida albicans reveals its involvement in virulence?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Stephanie Theiss; Marianne Kretschmar; Thomas Nichterlein; Herbert Hof; Nina Agabian; Jörg Hacker; Gerwald A. Köhler
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0950-382X)
- Published
- 2002
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)