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Patients diagnosed with Kawasaki disease before the fifth day of illness have a higher risk of coronary artery aneurysm by Yuichi Nomura; Kiminori Masuda; Masao Yoshinaga; Koji Sameshima; Koichiro Miyata is a Medicine article available to read on EtoBox.

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## Abstract **__Background__**: A fever lasting for at least 5 days is an essential characteristic of the original diagnostic criteria ofKawasaki disease (KD). However, it is not difficult for an experienced physician to confirm the diagnosis of KD before the fifth day offever. The aim of this study is to investigate the effect of intravenous gamma globulin therapy (IVGG) in KD initiated before the fifth day of illness. **__Methods__**: A total of 125 patients treated with IVGG were divided into group A (IVGG was initiated before the fifth dayof illness, __n__= 46) and group B (IVGG was initiated at the fifth day or after, __n__= 79). Patients’ characteristics,laboratory findings, treatments and outcomes were compared between the groups. **__Results__**: White blood cell count value, C‐reactive protein and Harada's score showed no difference between thegroups. A significantly higher average value of alanine aminotransferase (ALT) was observed in group A. Although the treatments were identicalin both groups, the average duration of fever from the initial day of IVGG in group A was significantly longer than in group B. Theincidence of aneurysm in group A was significantly higher than

Who reads Patients diagnosed with Kawasaki disease before the fifth day of illness have a higher risk of coronary artery aneurysm?

Author

Yuichi Nomura; Kiminori Masuda; Masao Yoshinaga; Koji Sameshima; Koichiro Miyata

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1328-8067)

Published

2002

Language

EN

Field

Medicine (Health Sciences)