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Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients by Maurizia Debiaggi; Filippo Canducci; Roberto Brerra; Michela Sampaolo; Maria Chiara Marinozzi; Maurizio Parea; Milena Arghittu; Emilio Paolo Alessandrino; Stefano Nava; Elisabetta Nucleo; Egidio Romero; Massimo Clementi is a Medicine article available to read on EtoBox.
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## Abstract Polyomaviruses KI (KIPyV) and WU (WUPyV) were described recently in children with acute respiratory disease. The pathogenic potential of these human viruses has not been determined completely, but a correlation between immunosuppression and virus reactivation has been suggested. In the present study, the association between KI/WUPyV infection and immunosuppression was investigated using sequential nasopharyngeal aspirates from asymptomatic adult hematopoietic stem cell transplant recipients. In parallel, an investigation on the WU/KIPyV prevalence in children with acute respiratory disease was also carried out. Two of the 126 samples obtained from the 31 hematopoietic transplant recipients were positive for KIPyV (1 sample, 0.79%) and WUPyV (1 sample, 0.79%). Both samples were obtained 15 days after allogeneic transplantation and virus persistence was not observed in subsequent samples. In symptomatic children, 7 of the 486 nasopharyngeal aspirates were positive for WUPyV (1.4%) and 1 for KIPyV (0.2%). Single polyomavirus infection was detected in four patients, whereas the remaining patients were co‐infected with respiratory syncityal virus (three patients) or adenovir
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- Author
- Maurizia Debiaggi; Filippo Canducci; Roberto Brerra; Michela Sampaolo; Maria Chiara Marinozzi; Maurizio Parea; Milena Arghittu; Emilio Paolo Alessandrino; Stefano Nava; Elisabetta Nucleo; Egidio Romero; Massimo Clementi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)